生体内における水銀の挙動について(I) HgCl2投与マウスの肝および腎におけるMercury Binding Proteinの分布とその変化

概要

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This is a report of the dynamic aspects of the selective accumulation of mercury binding protein in the kidney and liver from mice injected with HgCl2. Mercury present in the kideny and liver was bound to the low (M.W. about 10, 000) and high molecular weight fractions of supernatant on Sephadex G-75.At the start after dosing, a large amount of mercury in the kidney was bound to the high molecular weight protein, while mercury in the liver bound almost bisectionally to the both low and high molecular weight proteins. Mercury of the low molecular weight fractions of the kidney and liver increased gradually with time.In the mice repeatedly exposed, amount of mercury in the kidney increased in the low molecular weight fraction, but the distribution of mercury binding protein of the liver remained almost unchanged.
日本衛生学会の論文