フタル酸エステルの生体におよぼす影響マウス投与実験による病理組織学的検討

概要

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The effects of di-2-etyl-hexyl Phthalate (DOP) and di-butyl Phthalate (DBP) on the biological system of mice were histopathologically studied.DOP and DBP were added to the stock diet by giving the animals pellets made from the above diet. Both DOP and DBP were given to mice for 1-3 months at dose levels of about 5.0g/kg/day and about 0.5g/kg/day, repectively.Both DOP and DBP were found to cause marked lesions chiefly in the liver and kidney. In the large dose group, the liver showed remarkable vacuolar degeneration and necrosis of single cells, while the kidney showed cyst and degeneration of epithelial cells tubule. In the small dose group, although histological changes were slight in the liver and kidney, degeneration of parencyma was observed.The stage of histopathological findings between DOP and DBP was recognized by the striking disturbances of DOP in both large and small dosages. However, from the fact that remarkable changes were noted especially in the stage of cytoplasm, it is considered that both DOP and DBP are chemical substances that possibly cause cytotoxins in the body.The remarkable difference of lesions in the body was observed by the application of DOP and DBP. Regardless of the small dosage used for a long time, it became clear that both substances caused the increase of lesions in cytoplasm and in metabolic disturbances.
日本衛生学会の論文