和金(金魚)を使用した食品添加物その他に対する毒性試験

概要

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Japanese goldfish is adequate for toxicity testing in the field because of low cost and easiness in lethal effect testing compared with commonly used laboratory species such as mice or rats. 24-hr TLm for many food additives, poisons and inorganic compounds in goldfish were measured, and we demonstrated its usefulness for the field test in case like the powdered milk poisoning case which had occurred in Japan in 1955 with more than ten thousands injureds babies and one hundred and thirty deaths owing to contamination of preservatives added to milk with arsenic compounds. Further, by this method, lethal effects of mixed chemicals could be easily observed. For such an example, increased toxicity of sodium dodecyl benzene sulfonate in the presence of pentasodium tripolyphate was demonstrated.
日本衛生学会の論文