慢性カドミウム中毒の実験的研究 : 特にカルシウム欠乏との関係について

概要

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Some albino rats were fed with diet highly defficient in calcium and insufficient in protein. A certain quantity of cadmium dissolved in drinking water was given. After half a year they were sacrified to be examined pathologically.The most significant microscopical finding in kidney was the degeneration of tubules. In most cases the decalcification of bone was apparent, especially in female rats, some of which might have contracted osteomalacia.These findings may give a clue to the pathogenesis of so-called “Itai itai” disease.
日本衛生学会の論文