マウスにおけるメチルt-ブチルエ-テルの肝脂質過酸化反応への影響

概要

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The effect of one-shot or repeated treatment with methyl tertiary-butyl ether (MTBE) on lipid peroxidation and cytochrome P-450 in mouse liver was examined. One-shot treatment at the 500mg/kg dose level caused a transient decrease in leukocyte number after 24h. An increased level of lipid peroxide was observed in the liver homogenates 24h after one-shot treatment and four weeks of repeated 200mg/kg treatment.The hepatic cytochrome P-450 content increased after one and four weeks of repeated treatment (50, 200mg/kg). On the other hand, the treatment did not affect glutathione content and glutathione-S-transferase activity. These results indicate that MTBE treatment caused lipid peroxidation in the liver homogenate and induction of hepatic microsomal cytochrome P-450 content.
日本衛生学会の論文