THE EXPRESSION OF ICAM-1 ON HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINES

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Intercellular adhesion molecule-1 (ICAM-1) is one of the cell adhesion molecules. This molecule is a glycoprotein of about 90 KDa belonging to the immunoglobulin (Ig) superfamily and is widely expressed by hematopoietic and non-hematopoietic cells which play a role in the immune system. ICAM-1 is also a ligand or counter-receptor for the leukocyte integrin lymphocytefunction associated antigen-1 (LFA-1). We investigated the expression of ICAM-1 on the surfaces of cells from fifteen head and neck squamous carcinoma cell lines and the modulation of ICAM-1 expression by IFN-γ, using an immunohistochemical stain. We categorized four types of stain degree. (-): <10% of cells positive (±): 10-40% of cells positive (+): <40-70% of cells positive (++): >70% of cells positive Four cell lines showed (-) type. Three cell lines: (±). One cell line: (+). Seven cell lines: (++). The primary site of cell lines and the degree of ICAM-1 expression were not detectable. Connection between pathological differentiation and the degreed expression were not apparent, either. IFN-γup-regulated the degree of ICAM-1. All cell lines, when stimulated by IFN-γ, showed (++) type.
社団法人日本耳鼻咽喉科学会の論文