ラットへの水銀蒸気の暴露様式と水銀の体内分布ならびにその減少patternに関する実験的研究

概要

論文の詳細を見る
The author exposed rats to mercury vapor and measured mercury content in tissues. Exposure modes consisted of two groups; the HS, high concentration-short term exposure group (6.0mg/m3 in Hg concentration×1 hr. in daily duration of exposure, 3.0×1 and 1.5×1) and the LL, low concentration-long term exposure group (1.0×6, 1.0×3 and 1.0×1.5). Each exposure was continued 5 days a week for 2 or 4 consecutive weeks in an exposure chamber. Quantitative mercury determination was performed by a dithizone method. Mercury concentration of the lungs of the HS group after both the 2 and 4 weeks exposure was higher than that of the lungs of the LL group. That of the other tissues of the HS group was lower than that of the LL group. Mercury content in tissues of rats treated by the exposure mode 1.0×6 was measured up to 16 weeks after the termination of mercury exposure. The mercury content decreased lineally in semilogarithmic scales. The half time of mercury content of the lungs was about 13 days, the shortest and that of the brain was about 210 days, the longest among tissues.
日本衛生学会の論文