Synthesis and Biological Evaluation of Two Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation

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概要

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• Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, two analogues were prepared with the glucosamine and N-acetylglucosamine as glycosyl donor, 2-(4-hydroxyphenyl)ethanol as glycosyl acceptor. The effects of them over PC12 cell model exposed to hypoglycemia and serum limitation were assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Flow Cytometry and Western blot analysis.

• 公益社団法人　日本薬学会の論文

著者

• Guo Yibing

  Surgical Comprehensive Laboratory of Affiliated Hospital, Nantong University

• Li Xiaohong

  Surgical Comprehensive Laboratory of Affiliated Hospital, Nantong University

• Zhao Yahong

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

• Si Yongxing

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

• Zhu Hui

  Surgical Comprehensive Laboratory of Affiliated Hospital, Nantong University

• Yang Yumin

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

関連論文

• Synthesis and Biological Evaluation of Two Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation
• Synthesis, Biological Activity of Salidroside and Its Analogues
• Synthesis and Neuroprotective Effects of the Fluorine Substituted Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation

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