Synthesis, Biological Activity of Salidroside and Its Analogues

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概要

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• Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs–Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 μmol/l and 60 μmol/l, respectively.

• 公益社団法人　日本薬学会の論文

著者

• Zhao Yahong

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

• Yang Yumin

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

• Guo Yibing

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

• Zheng Cheng

  Institue of Nautical Medicine, Nantong University

• Meng Ying

  Jiangsu Key Laboratory of Neuroregeneration, Nantong University

関連論文

• Synthesis and Biological Evaluation of Two Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation
• Synthesis, Biological Activity of Salidroside and Its Analogues
• Synthesis and Neuroprotective Effects of the Fluorine Substituted Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation

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