Biotransformation of a Taxadiene by Ginkgo Cell Cultures and the Tumor Multi-Drug Resistant Reversal Activities of the Metabolites
スポンサーリンク
概要
- 論文の詳細を見る
The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, 1H- and 13C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.
著者
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Zhang Yi
State Key Lab Of Advanced Optical Communication Systems And Networks Shanghai Jiao Tong University
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Xie Dan
State Key Laboratory Of Oncology In South China Cancer Center Sun Yat-sen University
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Dai Jungui
State Key Lab. Of Bioactive Substances And Functions Of Natural Medicines Inst. Of Materia Medica Ch
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Chen Xiaoguang
State Key Lab. Of Bioactive Substances And Functions Of Natural Medicines Inst. Of Materia Medica Ch
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Zou Jianhua
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materi
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Yin Dali
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materi
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Xie Dan
State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical Co
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Zhang Yi
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Zou Jianhua
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Zou Jianhua
State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical Co
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Dai Jungui
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Xie Dan
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Chen Xiaoguang
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Yin Dali
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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