EFFECT OF GLYCYRRHIZIN ON ESTROGEN ACTION
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概要
- 論文の詳細を見る
It was demonstrated by the present study that glycyrrhizin inhibited the action of estradiol-17β on uterine weight and β-glucuronidase activity in ovariectomized mice and rats in a certain dose ratio. The inhibition was 50% or more when the dose ratio of glycyrrhizin: estradiol-17β was 1000: 1. In any higher ratio of glycyrrhizin to estrogen, the inhibition was decreased or even reversed. Glycyrrhizin by itself had no effect on either uterine weight or β-glucuronidase activity in ovariectomized mice. The mechanism of the anti-estrogenic effect was discussed in relation to the effect of glycyrrhizin on biological actions and hepatic degradation of cortisone.
- 社団法人 日本内分泌学会の論文
著者
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Yamamura Yuichi
The 3rd Department Of Medicine Osaka University Hospital
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KUMAGAI AKIRA
The 3rd Department of Internal Medicine Medical School of Osaka University
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NISHINO KAZUHIKO
The 3rd Department of Internal Medicine Medical School of Osaka University
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SHIMOMURA ATSUSHI
The 3rd Department of Internal Medicine Medical School of Osaka University
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KIN TAKEKAZU
The 3rd Department of Internal Medicine, Medical School of Osaka University
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YAMAMURA YUICHI
The 3rd Department of Internal Medicine, Medical School of Osaka University
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YAMAMURA YUICHI
The 3rd Department of Internal Medicine Medical School of Osaka University
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KUMAGAI AKIRA
The 3rd Department of Internal Medicine, Medical School of Osaka University
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NISHINO KAZUHIKO
The 3rd Department of Internal Medicine, Medical School of Osaka University
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