Inhibitory Effect of Ubiquinone on Biosynthesis of Aldosterone in Rat Adrenal <I>in vitro</I>
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概要
- 論文の詳細を見る
The effect of ubiquinone (Co Q<SUB>7</SUB>) was investigated in vitro on the biosynthesis of aldosterone from progesterone-4-<SUP>14</SUP>C and corticosterone-1, 2-<SUP>3</SUP>H using quartered rat adrenals. When progesterone was incubated with the adrenal tissue, the following metabolites could be obtained: 11-desoxycorticosterone, 11 β-hydroxyprogesterone, corticosterone, 18-hydroxycorticosterone and aldostei one. Ubiquinone inhibited the pi oduction of 18-hydroxycorticosterone and aldosterone with the resultant accumulation of corticosterone. This inhibitory effect of ubiquinone on the formation of aldosterone was more clearly observed when corticosterone was used as the substrate.<BR>These results suggest that ubiquinone inhibits the activity of 18-hydroxylase in the adrenal, resulting in the reduction of aldosterone biosynthesis.
- 社団法人 日本内分泌学会の論文
著者
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Yamamura Yuichi
The 3rd Department Of Medicine Osaka University Hospital
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KUMAGAI AKIRA
The 3rd Department of Internal Medicine Medical School of Osaka University
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NISHINO KAZUHIKO
The 3rd Department of Internal Medicine Medical School of Osaka University
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KIMM TAKEKAZU
The 3rd Department of Internal Medicine Medical School of Osaka University
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SHIMOMURA ATSUSHI
The 3rd Department of Internal Medicine Medical School of Osaka University
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NANAHOSHI MASAHISA
The 3rd Department of Internal Medicine Medical School of Osaka University
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YAMAMURA YUICHI
The 3rd Department of Internal Medicine Medical School of Osaka University
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