Diurnal Variation of Corticotropin-Releasing Activity in the Rat Hypothalamus
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概要
- 論文の詳細を見る
Diurnal periodicity of the hypothalamic content of corticotropin-releasing factor (CRF) was determined in the normal male rat by the intrapituitary microinjection method. It was found that the CRF activity in the rat hypothalamus showed a definite diurnal variation, having the peak value at about 18: 00 and the minimum at 4: 00 or 8: 00 under the lighting regimen of 6: 00 to 19: 00 of day light followed by 11 hrs. of darkness. The close temporal relationship with a definite phase shift observed between CRF activity and plasma corticosterone level appears to support the concept that the diurnal rhythm of the pituitary-adrenal axis is a direct reflection of the rhythmicity of CRF activity in the median eminence of the rat.
- 社団法人 日本内分泌学会の論文
著者
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ITOH SHINJI
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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Sakakura Muneki
Department Of Physiology Hokkaido University School Of Medicine
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Hiroshige Tsutomu
Department Of Physiology Hokkaido University School Of Medicine
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Itoh Shinji
Department Of Cardiology The Kitasato Institute Hospital
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