Increase of Urinary Insulin Excretion Following Probenecid Administration in Man

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概要

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• Oral administration of probenecid augmented urinary clearance of, trichloroacetic acid precipitable <SUP>131</SUP>I-insulin in six men who were injected with tracer dose of <SUP>131</SUP>I-insulin intravenously. The increments were 16 to 423 % above the control value (P<0.05). In other eight men, endogenous insulin in urine and plasma was measured by radioimmunoassay method. Apparently increased responses in urinary insulin excretion and urinary insulin clearance were observed after probenecid administration. The percentage increases of the insulin excretion and the insulin clearance beyond the control values were 2 to 200 (P<0.01) and 7 to 200 (P<0.01), respectively.<BR>It was suggested that insulin was reabsorbed at the proximal convoluted tubules and that probenecid affected this reabsorption mechanism.

• 社団法人 日本内分泌学会の論文

著者

• MASHIMO Keimei

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• HORIUCHI YOSHIHIKO

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• HORIUCHI YOSHIHIKO

  Second Department of Medicine, Hokkaido University School of Medicine

• MASHIMO KEIMEI

  Second Department of Medicine, Hokkaido University School of Medicine

• Setaishi Chitoshi

  Second Department of Medicine, Hokkaido University School of Medicine

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• Increase of Urinary Insulin Excretion Following Probenecid Administration in Man

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