Persistence of Diurnal Periodicity of CRF Activity in Adrenalectomized and Hypophysectomized Rats

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概要

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• Diurnal variations of CRF activity in the median eminence were observed not only in normal, but also in adrenalectomized and hypophysectomized male rats. The presence of circadian rhythm in CRF activity in the absence of the pituitary and adrenal gland suggests that the circadian rhythmicity of ACTH release is controlled by higher centers. The levels of CRF stores in hypophysectomized rats at any time of the day were markedly more increased than those in adrenalectomized and intact rats. This phenomenon suggests that CRF stores in the hypothalamus were inhibited by ACTH via short feedback mechanism. Furthermore, the peak of CRF stores in adrenalectomized and hypophysectomized rats showed a phase shift toward the earlier period of day. This finding may represent a shift of this rhythm secondary to the absences of the adrenal gland and the pituitary gland.

• 社団法人 日本内分泌学会の論文

著者

• MASHIMO Keimei

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• TAKEBE KAZUO

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• SAKAKURA MUNEKI

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• HORIUCHI YOSHIHIKO

  Second Department of Internal Medicine, Hokkaido University School of Medicine

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