Comparison of Ovulation-inducing Effect between Estrogen and Progestin in the Ovulation-Blocked Rat by Chlorpromazine

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A single injection of non-sedative dose of chlorpromazine hydrochloride (CPZ) on the day of proestrus delayed the spontaneous ovulation by about 24hr in the 4-day cycling rat under the controlled lighting (14L:10D, light on 07:30-21:30). The single doses of CPZ injected subcutaneously from 09: 30 to 16: 30 (or intravenously to 17:30) on the day of proestrus, produced the dose-dependent increase in number of the animals blocked their ovulation. The retardation of injection time during this period increased incidence of the ovulation-blocked rat. At 15:30 and 16: 30, a single subcutaneous dose of 0.15mg CPZ blocked ovulation in all of the rats. After 17:30, the blocking effect of CPZ decreased, and at 20:30, even the sedative dose, 4.8mg did not block ovulation.<BR>Ovulation-inducing effects of various estrogens and progestins were investigated in these CPZ-blocked rats. Incidence peak of ovulation, induced in 45% of the animals, was found at the dose of 64μg estrone, and no ovulation was obtained at the doses either below 8μg or above 512μEg. Estradiol benzoate and Premarin both in a wide range of doses showed the ovulation-inducing effect. Clomiphene citrate in the doses used did not practically induce ovulation. Though the estrogens used except clomiphene citrate were effective, the incidence of induced ovulation were considerably low. On the other hand, progesterone and dydrogesterone were highly effective to evoke the complete ovulatory response in all of the animals. Norethindrone was relatively less effective and testosterone did not induce ovulation.
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Comparison of Ovulation-inducing Effect between Estrogen and Progestin in the Ovulation-Blocked Rat by Chlorpromazine

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