Effect of L-Dopa on Anterior Pituitary Hormone Release in Man

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The response of GH, TSH, FSH and LH secretion to L-dopa administration was investigated in 14 normal subjects and 9 patients with Parkinsons disease in order to evaluate this catecholamine precursor as a pituitary function test. The oral administration of 0.5 or 1.0g L-dopa stimulated GH release in 6 out of 10 normal individuals and 4 out of 6 patients. The peak levels of plasma GH were observed between the periods of 30-90 min after L-dopa, and the peak values of plasma GH were 8.9±1.9ng/m<I>l</I> in normal subjects and 8.1±2.3 in the patients, but the peak GH levels were less than those observed in the cases of arginine load or insulin-induced hypoglycemia. The remaining 6 subjects and 5 cases (2 normals and 3 patients) who received a single intravenous administration of 50mg L-dopa showed minimal response to L-dopa. Blood glucose, plasma TSH, FSH, LH and insulin levels did not change significantly after the L-dopa administration in all cases, including the subjects in whom plasma GH levels were elevated by L-dopa. Three normal females with normal menstrual cycle were examined in their follicular and luteal phases, but showed no response in plasma FSH and LH secretion to L-dopa in either phase.<BR>These results indicate that L-dopa has a relatively great potential as a provocative agent for stimulating GH release but only a limiting merit as a pituitary function test because of less reliability than arginine or insulin-induced hypoglycemia. The L-dopa has no significant effect on TSH, FSH and LH secretion in man.
社団法人日本内分泌学会の論文

Effect of L-Dopa on Anterior Pituitary Hormone Release in Man

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