Effects of D-glucuronolactone, L-gulonolactone and Pentitols on Insulin Secretion in Dogs

スポンサーリンク

概要

• 論文の詳細を見る

• Intravenous administration of 0.4g/kg D-glucuronolactone or L-gulonolactone, the precursors of xylitol in the glucuronate-xylulose cycle, produced only small increases in plasma insulin in dogs. The plasma insulin responses were far less than those following the equivalent dose of xylitol, and are presumably explained by the concomitant small rises in plasma glucose. Infusions of ribitol, L-arabitol or D-arabitol (2mg/kg. min) into the pancreatic artery of dogs did not produce any significant increases in plasma insulin concentration in the pancreatic vein, while xylitol and glucose infused in a similar manner always stimulated insulin release. These data appear against the direct involvement of the glucuronate-xylulose cycle or the pentose phosphate pathway in the mechanism of insulin secretion. The mechanism of strong insulin-releasing effect of xylitol in dogs remains unexplained.

• 社団法人 日本内分泌学会の論文

著者

• KANAZAWA YASUNORI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KIKUCHI MASATOSHI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KUZUYA TAKESHI

  Department of Internal Medicine, Jichi Medical School

• IDE TAKEHIKO

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• Reduction of C-Peptide Secretion in Noninsulin-Dependent Diabetic Patients with Long Duration of Insulin Treatment
• Insulin Secretory Responses in Patients with Glucose Intolerance due to Extra-Pancreatic Causes. Comparison with Idiopathic Diabetes Mellitus
• Effects of D-glucuronolactone, L-gulonolactone and Pentitols on Insulin Secretion in Dogs
• Species Difference in Plasma Insulin Responses to Intravenous Xylitol in Man and Several Mammals

スポンサーリンク