Reduction of C-Peptide Secretion in Noninsulin-Dependent Diabetic Patients with Long Duration of Insulin Treatment

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概要

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• We examined the responses of serum free C-peptide immunoreactivity (CPR) during a 100g oral glucose tolerance test (OGTT) on diabetic patients undergoing different kinds and durations of treatment. None of the patients were ketosis-prone or had any history of nephropathy and they all developed diabetes when over the age of 30. The Σ serum free CPR (the sum of serum free CPR values during OGTT) of group A (duration of insulin treatment was less than 5 years, N=10) was found to be higher than that of group B (duration of insulin treatment was 5 years or more, N =10)(p<0.005). On the other hand, the Σ serum free CPR of group C (treatment with an oral hypoglycemic agent for less than 5 years, N=9) was not statistically different from that of group D (treatment with an oral hypoglycemic agent for 5 years or more, N=11). There were no statistical differences between group A and group B in age at onset, duration of diabetes, daily insulin dose, relative body weight index, serum creatinine or ΣBG (the sum of blood glucose values during OGTT). Just before the start of insulin treatment, there were no significant differences between the two groups in the following: 1. fasting blood glucose values (all 10 patients measured in group A and 9 patients in group B) 2. blood glucose and plasma immunoreactive insulin (IRI) responses (7 patients measured in group A and 6 in group B). Among those with plasma IRI measured on the previous occasion, Σserum free CPR was found to be higher in group A than in group B (p<0.025) at the time of the present study. A negative correlation was noted between the duration of insulin treatment and Σserum free CPR in insulin-treated patients (r=-0.39, p<0.05). Thus, pancreatic B-cell function in insulin-treated noninsulin-dependent diabetic patients is likely to be inversely correlated with the duration of insulin treatment.

• 社団法人 日本内分泌学会の論文

著者

• Iwamoto Yasuhiko

  Third Department Of Internal Medicine Tokyo Women's Medical University

• HSIEH SHIUN

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• AKANUMA YASUO

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KAWAZU SHOJI

  Third Department of Internal Medicine, Saitama Medical School

• MASHIKO SHIGERU

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KANAZAWA YASUNORI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KIKUCHI MASATOSHI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KOSAKA KINORI

  Third Department of Internal Medicine, Toranomon Hospital

• IWAMOTO YASUHIKO

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

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• Reduction of C-Peptide Secretion in Noninsulin-Dependent Diabetic Patients with Long Duration of Insulin Treatment
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• Effects of D-glucuronolactone, L-gulonolactone and Pentitols on Insulin Secretion in Dogs
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• Basic peptide with insulin-like activity in human serum.

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