A Possible Involvement of Adrenaline in the Facilitation of Lordosis Behavior in the Ovariectomized Rat

概要

論文の詳細を見る
In order to examine a possible role of adrenaline (AD) or noradrenaline (NA) in the control of lordosis behavior, lordosis quotient (LQ) was observed daily for 8 consecutive days in the ovariectomized rat given daily 1 or 2μg/0.1m<I>l</I> oil of estradiol benzoate (EB) alone or together with 100μg/0.1m<I>l</I> saline of AD or NA. AD but not NA treated together with EB caused a greater change in the daily LQ than the same dose of EB alone and the change in the daily LQ by daily treatment with both 1μg EB and 100μg AD was equivalent to that by daily treatment with 2μg EB alone. A half mg progesterone (P) could induce the lordosis behavior in the ovariectomized rat treated 48 hr prior with both 1μg EB and 50 or 100μg AD, but not in the one treated with 1μg EB alone. While 50, 100 or 200μg NA or 10μg AD had no effect, 50 or 100 pg AD pretreated together with 2 pg EB produced a markedly higher LQ after p than 2μg EB alone in the ovariectomized rat. This effect of AD on the induction of lordosis behavior was produced only when AD was pretreated simultaneously with EB and AD priming 24 or 43 hr after EB failed to elicit the effect. Therefore, it is suggested that a change of the brain target site in the estrogen sensitivity produced by AD plays a part in the control of lordosis behavior.
社団法人日本内分泌学会の論文