The Stimulatory Roles of Catecholamines and Acetylcholine in the Regulation of Gonadotropin Release in Ovariectomized Estrogen-primed Rats

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概要

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• Injections of 2mg of progesterone into ovariectomized estrogen-primed rats significantly increased serum LH and FSH concentrations 3, 5 and 8hr later. Receptor blockers of noradrenaline (NA), dopamine (DA) or acetylcholine (ACH), phenoxybenzamine (20mg/kg body weight), pimozide (1mg/kg body weight) or atropine (700 mg/kg body weight), respectively, prevented the progesterone-induced gonadotropin release. On the other hand, none of them blocked the gonadotropin release following unilateral electrochemical stimulation (100μA for 60sec) of the medial preoptic area which occurred 0.5 and 1.5hr later, although pimozide or atropine reduced serum LH concentrations at 4.0hr after stimulation.<BR>Furthermore, the sites of action of NA, DA and ACH with respect to LH release were examined by intracerebral implantation in ovariectomized estrogen-primed rats. DA or ACH, when implanted unilaterally into the medial preoptic area, induced a significant increase in serum LH 5hr later, whereas NA decreased LH levels. Implantations of NA or ACH into the bed nucleus of the stria terminalis or the medial amygdala increased serum LH although the effect of NA into the latter was not statistically significant. Only implantations of NA among the three substances into the lateral septum induced LH release.<BR>These results suggest that all of NA, DA and ACH play stimulatory roles in the regulation of gonadotropin secretion, and that there are regional differences of their effectivenesses in releasing L H within the limbic-preoptic area.

• 社団法人 日本内分泌学会の論文

著者

• Kawakami Masazumi

  Second Department of Physiology, Yokohama University School of Medicine

• ARITA JUN

  Second Department of Physiology, Yokohama City University School of Medicine

• KIMURA FUKUKO

  Second Department of Physiology, Yokohama City University School of Medicine

• HAYASHI REIKO

  Second Department of Physiology, Yokohama City University School of Medicine

• Kawakami Masazumi

  Second Department Of Physiology Yokohama University School Of Medicine

• KAWAKAMI MASAZUMI

  Second Department of Physiology, Yokohama City University School of Medicine

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• The Effect of Brain Lesions upon the Spontaneous EEG-afterreaction in Rabbits Treated with Sex Hormones
• The Stimulatory Roles of Catecholamines and Acetylcholine in the Regulation of Gonadotropin Release in Ovariectomized Estrogen-primed Rats
• Effects of Diethyldithiocarbamate (DDC), Fusaric Acid, Catecholaminergic and Serotonergic Receptor Blockers on the Ascending Pathway from the Ventrolateral Part of the Medulla Oblongata
• Estrogen-Sensitive Neurons with Preoptic Projection in the Lower Brain Stem of the Female Rat
• Negative Feedback Effects of Chlormadinone Acetate and Ethynylestradiol on Gonadotropin Secretion in Patients with Prostatic Cancer and Male Rats

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