Estrogen-Sensitive Neurons with Preoptic Projection in the Lower Brain Stem of the Female Rat

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概要

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• Fifty-one neurons in the ventrolateral part of the medulla oblongata were antidromically activated by electrical stimulation of the suprachiasmatic part of the preoptic area in urethane-anethetized, ovariectomized and estrogen-primed female rats. Two types of antidromic responses were distinguished on the basis of their spike configurations and antidromic spike latencies. One type (“fast spikes”) was characterized by a fast and smooth rising phase and a shorter duration of the initial positive deflection. The othe type (“slow spikes”) had a notch in the rising phase and took a longer time to complete the initial deflection. Mean antidromic spike latency for the fast spikes was 9.8 msec while the value for the slow spikes was 30.2msec. Ionophoretic injection of estradiol was accomplished on 37 of the 51 antidromically identified cells, of which 21 showed slow responses and 16 responded with fast spikes. In cells with slow spikes, estradiol facilitated (n=9) or suppressed (n=3) their generation of action potentials. None of cells with fast responses changed their activity in response to estradiol. It is evident from the present experiment that neurons in the ventrolateral part of the medulla oblongata send their axons directly to the suprachiasmatic part of the preoptic area which plays an important role in the control of the ovulatory surge of LH and that some of these neurons themselves are the sensitive sites of estradiol.

• 社団法人 日本内分泌学会の論文

著者

• Kawakami Masazumi

  Second Department of Physiology, Yokohama University School of Medicine

• OHNO SHIRO

  Second Department of Physiology, Yokohama City University School of Medicine

• Kawakami Masazumi

  Second Department Of Physiology Yokohama University School Of Medicine

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• The Stimulatory Roles of Catecholamines and Acetylcholine in the Regulation of Gonadotropin Release in Ovariectomized Estrogen-primed Rats
• Effects of Diethyldithiocarbamate (DDC), Fusaric Acid, Catecholaminergic and Serotonergic Receptor Blockers on the Ascending Pathway from the Ventrolateral Part of the Medulla Oblongata
• Estrogen-Sensitive Neurons with Preoptic Projection in the Lower Brain Stem of the Female Rat
• Negative Feedback Effects of Chlormadinone Acetate and Ethynylestradiol on Gonadotropin Secretion in Patients with Prostatic Cancer and Male Rats

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