Prolonged Stimulation of Adenylate Cyclase Activity and Testosterone Production by Cholera Enterotoxin with Suppression of Gonadotropin Release in Rats
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概要
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Endocrine effects of cholera enterotoxin (CET) on male gonads were investigated in normal and hypophysectomized rats. After intratesticular injection of 5μg of CET in the bilateral testes of normal rats, serum testosterone concentration remarkably increased after 24 hr, remained significantly elevated for at least3 days and returned to the control level in7days. Serum LH level decreased in the undetectable range after1-3days; serum FSH level also significantly decreased after3days. Both gonadotropin levels increased28days after the injection, when the CET-injected testis decreased in weight and was accompanied by marked loss of germinal cells.<BR>When 5μg of CET was injected intratesticularly in the bilateral testes of hypophysectomized rats, adenylate cyclase activity of a CET-injected testis was remarkably stimulated after6hr, remained four times elevated for at least3days and returned to the control level in7days. In relatively good accordance with the increase in adenylate cyclase activity, testosterone content remarkably enhanced in the CET-injected testis.<BR>These <I>in vivo</I> data indicate that the intratesticular injection of CET prolongedly stimulates the adenylate cyclase activity of testicular cells including Leydig cells and increases testosterone production, and suggest that the prolonged enzyme stimulation results in the sustained elevation of serum testosterone concentration for at least 3 days, causing the stimulation of the negative feedback mechanism ofhypophysealtesticular axis to decrease serum LH levels in the undetectable range.
- 社団法人 日本内分泌学会の論文
著者
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OHSAWA NAKAAKI
The Third Department of Internal Medicine, University of Tokyo Faculty of Medicine
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SATO KANJI
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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OHSAWA NAKAAKI
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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