The Release and Metabolism of Pancreatic Hormones After Major Hepatectomy in the Dog

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概要

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• Major hepatectomy in the dog induced a 50% decrease in peripheral serum glucose, all-fold increase in portal plasma glucagon and a 36-fold increase in the portal glucagon/insulin ratio 3hr after operation. Peripheral serum glucose levels were inversely correlated to the logarithmic value of portal plasma glucagon (r=-0.50, p<0.01) and that of the portal glucagon/insulin ratio (r=-0.85, p<0.01) for 1-6hr after operation. The ratio of peripheral to portal plasma glucagon was also inversely correlated to the logarithmic value of portal plasma glucagon (r=-0.59, p<0.01). In case of glucose infusion, plasma glucagon levels were not elevated after major hepatectomy.<BR>The data suggest that glucose deficiency after major hepatectomy in the dog may cause hyperglucagonemia with an enhanced glucagon requirement.

• 社団法人 日本内分泌学会の論文

著者

• ITATSU TAKEHARU

  Frist Department of Internal Medicine, Nagoya University School of Medicine

• KISHIMOTO TAKEHIKO

  Second Department of Surgery, Nagoya University School of Medicine

• SHINTANI TSUYOSHI

  Second Department of Surgery, Nagoya University School of Medicine

• UKAI MITSUO

  Institute of Germfree Life Research, Nagoya University School of Medicine

• UKAI MITSUO

  Institute of Cermfree Life Research, Nagoya University Scholl of Medicine

関連論文

• The Release and Metabolism of Pancreatic Hormones After Major Hepatectomy in the Dog
• The Histaminergic Mechanism of Neurotensin-induced Glucagon Release from Isolated Rat Pancreatic Islets

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