The Histaminergic Mechanism of Neurotensin-induced Glucagon Release from Isolated Rat Pancreatic Islets

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概要

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• Isolated rat pancreatic islets were preincubated in a medium with 16.7mM glucose and incubated with 5.5mM glucose. Both histamine (100μ M) and neurotensin (100nM) stimulated glucagon release from the isolated islets, but not insulin release. The stimulation of glucagon release occurred in the presence of 10 and 100nM neurotensin, while the release of insulin was inhibited in the presence of 1 and 10nM neurotensin. The neurotensin-induced glucagon release was completely inhibited by 1mM metiamide, an histamine H<SUB>2</SUB>-receptor antagonist, added to the incubation medium and not inhibited by 1mM diphenhydramine, an histamine H<SUB>1</SUB>-receptor antagonist.<BR>The results indicate that the histaminergic mechanism, including the H<SUB>2</SUB>-receptor system, may be involved in neurotensin-induced glucagon release from the endocrine pancreas.

• 社団法人 日本内分泌学会の論文

著者

• UKAI MITSUO

  Institute of Germfree Life Research, Nagoya University School of Medicine

• ITATSU TAKEHARU

  Department of Internal Medicine, Nagoya Second Red Cross Hospital

• SHIBATA ATSUMI

  Department of Internal Medicine, Nagoya East City Hospital

• UKAI MITSUO

  Institute of Cermfree Life Research, Nagoya University Scholl of Medicine

関連論文

• The Release and Metabolism of Pancreatic Hormones After Major Hepatectomy in the Dog
• The Histaminergic Mechanism of Neurotensin-induced Glucagon Release from Isolated Rat Pancreatic Islets

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