Evaluation of L-Thyroxine Requirement in Treatment of Congenital Hypothyroidism
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概要
- 論文の詳細を見る
The optimal daily requirement of L-T<SUB>4</SUB> in replacement therapy for hypothyroidism was evaluated in evaluated in 24 cases of congenital hypothyroidism and 3 of juvenile myxedema, ranging from 3 to 30 years of age.<BR>The optimal dose of L-T<SUB>4</SUB>, defined as the minimal dose necessary to suppress the serum concentration of TSH into the normal range, was determined in each patient. The optimal dose of L-T<SUB>4</SUB> between 3 and 5 years of age was 5-7μg/kg/day, which was higher than a level of 2-4μg/kg/day in adult.<BR>All patients appeared clinically euthyroid, and their serum concentration of T<SUB>4</SUB> and T<SUB>3</SUB> remained within the normal range while the optimal dose of L-T<SUB>4</SUB> was being administered.<BR>These observations imply that physiologic requirement of L-T<SUB>4</SUB> are lower than previously recommended dosages.<BR>Further studies to establish more precise therapeutic guidelines are needed.
- 社団法人 日本内分泌学会の論文
著者
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NAKAJIMA Hironori
Department of Mechanical Engineering, Kyushu University
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Niimi Hiroo
Department Of Pediatrics School Of Medicine Chiba University
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Niimi Hiroo
Department Of Pediatrics Chiba University School Of Medicine
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Sasaki Nozomu
Department Of Pediatrics Saitama Medical College
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Harada N
Fujita Health Univ. Toyoake Jpn
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Noda Hiromasa
Department Of Pediatrics Funabashi Central Hospital
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Inomata Hiroaki
Department Of Pediatrics Ichihara Hospital Of Teikyo University School Of Medicine
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Niimi H
Chiba Univ.
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Sasaki Nozomu
Department of Pediatric Cardiology and Cardiovascular Surgery, Saitama Heart Institute, Saitama Medical School Hospital
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SASAKI NOZOMU
Department of Pediatrics, School of Medicine, Chiba University
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INOMATA HIROAKI
Department of Pediatrics, School of Medicine, Chiba University
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