The Inhibitory Effect of Disodium Cromoglycate on the Growth of Chlamydophila (Chlamydia) pneumoniae in Vitro(Microbiology)
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概要
- 論文の詳細を見る
Chlamydophila (Chlamydia) pneumoniae is associated with asthma and several other respiratory illnesses. Disodium cromoglycate (DSCG) is known to inhibit both immediate and late asthmatic responses. In this study, the inhibitory effect of DSCG on the growth of C. pneumoniae was examined by minimum inhibitory concentration (MIC) and pre-inoculation minimal cidal concentration (MCC) assays using HL cells and C. pneumoniae AR-39. DSCG below the clinically relevant concentration inhibited the growth of C. pneumoniae in a dose-dependent manner in both the MCC and MIC assays. The inhibitory effect was also time-dependent in the MCC assay at 20 mg/ml of DSCG. These results warrant further clinical study on the connection between C. pneumoniae infections and use of DSCG.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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SASAKI NOZOMU
Department of Pediatrics, Saitama Medical University
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Sasaki Nozomu
Department Of Pediatrics Saitama Medical College
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Kishimoto T
National Institute Of Infectious Diseases
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Yamazaki Tsutomu
National Inst. Infectious Diseases Tokyo Jpn
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Yamazaki Tsutomu
National Institute Of Infectious Diseases:department Of Pediatrics Saitama Medical School
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YAMAGUCHI Tetsuya
National Institute of Infectious Diseases
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INOUE Miyuki
Department of Pediatrics, Saitama Medical School
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SATO Kozue
National Institute of Infectious Diseases
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KISHIMOTO Toshio
National Institute of Infectious Diseases
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Inoue Miyuki
Department Of Pediatrics Saitama Medical School
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Kishimoto Toshio
National Inst. Infectious Diseases Tokyo Jpn
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Sasaki N
Saitama Medical School Saitama Jpn
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Sasaki Nozomu
Department of Pediatric Cardiology and Cardiovascular Surgery, Saitama Heart Institute, Saitama Medical School Hospital
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Sasaki Nozomu
Department of Pediatrics, Saitama Medical School
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