Portal Somatostatin Reponds to Intragastric Glucose: Effects of Streptozotocin Diabetes
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概要
- 論文の詳細を見る
Changes in somatostatin levels in portal plasma in response to intragastric glucose loading were examined in normal controls and streptozotocin diabetic rats of one week duration.<BR>The mean (±SEM) basal level of somatostatin was more significantly elevated in diabetic rats (401±62 pg/m<I>l</I>) than in controls (171±13 pg/m<I>l</I>). However, no significant difference in somatostatin concentrations 30 min after glucose loading was found between diabetic and control animals (587±113 vs. 443±47 pg/m<I>l</I>). Glucose loading caused a significant elevation of somatostatin in controls, but not in diabetic rats.<BR>These results suggest a physiologic role of somatostatin in nutrient homeostasis, and that abnormalities in D cell function are present in streptozotocin diabetes of short duration.
- 社団法人 日本内分泌学会の論文
著者
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KAZUMI TSUTOMU
Second Department of Internal Medicine, Kobe University School of Medicine
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YOSHINO GEN
Second Department of Internal Medicine, Kobe University School of Medicine
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BABA SHIGEAKI
Second Department of Internal Medicine, Kobe University School of Medicine
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UTSUMI MASAFUMI
Second Department of Internal Medicine, Kobe University School of Medicine
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ISHIHARA KAZUHIDE
Second Department of Internal Medicine, Kobe University School of Medicine
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MAKIMURA HIROYUKI
Second Department of Internal Medicine, Kobe University School of Medicine
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