A Case of Primary Hyperparathyroidism with Low Serum Alkaline Phosphatase Levels
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概要
- 論文の詳細を見る
A 23-year-old man with primary hyperparathyroidism which was typical except for reduced alkaline phosphatase activity is reported. Histological examination of surgical specimens revealed chief cell hyperplasia of the parathyroid glands. Systemic abnormalities of alkaline phosphatase were demonstrated, i. e., marked reduction of all isoenzymes and undetectable osseous enzyme in the serum, abnormal distribution of the enzyme in hepatocytes and diminished enzyme activities in leukocytes. In addition, diminished bone remodeling activity was revealed in a biopsy specimen of the rib. The association of hypophosphatasia is highly unlikely, because of normal urinary excretion of phosphoethanolamine, lack of osteomalacia, and no indication of an hereditary factor. The causal relationship between low remodeling activity and abnormalities in alkaline phosphatase was suggested.
- 社団法人 日本内分泌学会の論文
著者
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Kuzuya Nobuaki
東京医科大学動物実験センター
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Kuzuya Nobuaki
Omiya Medical Center Jichi Medical School
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Yamashita Kamejiro
Institute of Clinical Medicine, University of Tsukuba
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KIMURA Satoshi
Institute of Medical Science, University of Tokyo
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Yamashita Kamejiro
Institute Of Clinical Medicine University Of Tsukuba
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KUGAI NOBUO
Institute of Clinical Medicine, University
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KAWAI KOICHI
Institute of Clinical Medicine, University
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OGATA ETSURO
Institute of Clinical Medicine, University of Tsukuba
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YOSHIKAWA SEIZO
Institute of Clinical Medicine, University of Tsukuba
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FUJIMOTO YOSHIHIDE
Institute of Clinical Medicine, University of Tsukuba
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KAWAI KOICHI
Institute of Clinical Medicine, University of Tsukuba
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- A Case of Primary Hyperparathyroidism with Low Serum Alkaline Phosphatase Levels