Inhibition by Trifluoperazine of Glycogenolytic Effects of Phenylephrine, Vasopressin, and Angiotensin II
スポンサーリンク
概要
- 論文の詳細を見る
The effects of trifluoperazine on the activation of glycogenolysis by various hormones were studied in perfused rat liver. Trifluoperazine significantly inhibited glycogenolytic effect of phenylephrine and angiotensin II by lowering maximal response, and that of vesopressin by shifting the dose-response curve to the right, while α-antagonist phentolamine was inhibitory only to phenylephrine. Phosphorylase activation of phenylephrine was inhibited by trifluoperazine in parallel with glycogenolytic response. The increase in <SUP>45</SUP>Ca<SUP>2+</SUP> efflux induced by phenylephrine, angiotensin II, and vasopressin was also inhibited by the agent. These inhibitory effects of trifluoperazine were not related to the change in tissue cyclic AMP or cyclic GMP levels. On the other hand, neither the glycogenolytic effect of glucagon, cyclic AMP, and N<SUP>6</SUP>, O<SUP>2</SUP>-dibutyryl cylic AMP nor phosphorylase activation by glucagon was affected by trifluoperazine. Thus, trifluoperazine specificially inhibits the activation of glycogenolysis by Ca<SUP>2+</SUP>-dependent hormones.
- 社団法人 日本内分泌学会の論文
著者
-
Yamashita Kamejiro
Institute Of Clinical Medicine University Of Tsukuba
-
KIMURA SATOSHI
Endocrinology Division, National Cancer
-
KOIDE YOSHINOBU
Institute of Clinical Medicine, University
-
KUGAI NOBUO
Institute of Clinical Medicine, University
-
TADA RYOKO
Institute of Clinical Medicine, University of Tsukuba
関連論文
- P304 CARDIOVASCULAR MANIFESTATIONS OF THYROID HEART AND THEIR LATE CLINICAL COURSE
- 0501 CHRONIC EFFICIENCY OF ALDOSE REDUCTASE INHIBITOR FOR EXERCISE CAPACITY IN PATIENTS WITH DIABETES MELLITUS : A SINGLE BLIND STUDY
- EFFICIENCY OF ALDOSE REDUCTASE INHIBITOR FOR EXERCISE TOLERANCE IN PATIENTS WITH DIABETES MELLITUS
- Refractoriness to Phosphaturic Action of Parathyroid Hormone Occurring Independent of Phosphate Depletion in Hyperparathyroid Rats
- Association of Isolated Adrenocorticotropin Deficiency with a Variety of Neuro-Somatic Abnormalities in Congenital Facial Dinlezia (Moebius) Syndrome
- Inhibition by Trifluoperazine of Glycogenolytic Effects of Phenylephrine, Vasopressin, and Angiotensin II
- Hyponatremia without Inappropriate Secretion of Vasopressin in a Case of Myxedema Coma
- Stimulatory Effect of Pertussis Toxin on Tissue Cyclic AMP Levels in Canine Thyroid Slices
- Inhibitory Effects of 1α, 25-Dihydroxycholecalciferol on Parathyroid Hormone Secretion in Rats
- A Case of Primary Hyperparathyroidism with Low Serum Alkaline Phosphatase Levels
- Inhibitory effect of calcium channel blockers on .ALPHA.-adrenergic activation of glycogenolysis and calcium efflux in perfused rat liver.