Various Phenotypes of Diabetes Mellitus as Ultimate Outcome of Acutely Developed Diabetic State Induced by Viral Infection

概要

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For 4 to 8years we followed up 3 diabetic patients in whom the onset of diabetes seemed to be closely related to the well-documented Epstein-Barr virus infection (Case 1) or Coxsackie B4 virus infection (Case 2, 3). Although all developed acute ketosis-prone diabetes in the convalescent stage of the viral infections, the subsequent clinical courses were quite different from each other. Case 1 has remained consistently insulin-dependent and associated with positive islet cell antibody, gastric parietal cell antibody, thyroglobulin hemoagglutinating antibody and thyroidal microsomal hemoagglutinating antibody. Case 2 restored normal glucose tolerance. Case 3 has become noninsulin-dependent diabetes mellitus after a 6year interval. Thus, it is reasonably presumed that viruses could be responsible for the occurrence of different phenotypes of diabetes.
社団法人日本内分泌学会の論文