Heterogeneity of Glucagon and Insulin
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概要
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The heterogeneity of glucagon and insulin in plasma and tissue extracts from a 57-year-old female with glucagonoma syndrome with surgically and autopsy verified islet-cell tumors was studied by Bio-Gel P-10 filtration. The preoperative plasma immunoreactive glucagon (IRG) level was 20.2ng/m<I>l</I>, and plasma glucagon-like immunoreactivity (GLI) 25.8ng/m<I>l</I>. The column chromatography of the preoperative plasma revealed three or four IRG components and four GLI components. Among these, peak II, the large glucagon immunoreactivity (LGI) peak, considered a candidate for proglucagon, was prominent, along with peak III.<BR>The resected metastastatic liver tumor contained an enormous amount of IRG and an appreciable amount of immunoreactive insulin (IRI), indicating that the elevated plasma IRG was mainly of tumor origin.<BR>The IRG pattern of the tumor tissue extract revealed a small quantity of IRG in peaks I and II, and a large amount in peak III; control pancreatic tissue extract manifested a similar elution pattern. The IRI elution pattern of the tumor tissue extract revealed two major IRI peaks which migrated close to the elution volume of cytochrome C and insulin, respectively. This is a quite different pattern from the control pancreatic tissue extract in which the IRI peak was localized in the elution volume of the insulin.<BR>We conclude that the present metastatic liver tumor produced not only enormous amounts of glucagon but heterogeneous peptides which contained immunological insulin determinants within thei.
- 社団法人 日本内分泌学会の論文
著者
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Fukushima Hideo
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Uzawa Haruo
Department Of Internal Medicine Institute Of Constitutional Medicine Kumamoto University
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YAMAGUCHI Kohei
Department of Endocrinology and Metabolism, Oita Prefectural Hospital
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Yamaguchi Kohei
Department Of Civil And Structural Engineering Faculty Of Engineering Kyushu University
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UZAWA HARUO
Department of Geriatrics, Institute of Constitutional Medicine, Kumamoto University
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YAMAGUCHI KOHEI
Department of Internal Medicine, Institute of Constitutional Medicine, Kumamoto University
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FUKUSHIMA HIDEO
Department of Internal Medicine, Institute of Constitutional Medicine, Kumamoto University
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