Lack of Inhibitory Effect of Exogenous Prolactin on Ovarian Responsiveness to Gonadotropins in the Rat

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Attempts were made to elucidate the possible antigonadotropic action of PRL at the ovarian level. Immature female rats of Wistar strain were injected subcutaneously with PMS (5-10i. u.) at 0900h on day 23 of age, followed an intraperitoneal injection of HCG (5-10 i. u.) at 1400h on day 25. In all animals treated with PMS-HCG, ova were found in the oviducts when examined at 0900h on day 26 of age. Rat PRL was administered either at various doses (1.0-20μg/day) in the morning (0800h) between day 23-25 or at 5μg/day for 10 days prior to HCG injection. The ability of exogenous gonadotropins to induce ovulation and weight gain of the ovary were not affected by this PRL treatment. In animals injected with PMS, significant rises in serum estradiol-17β levels were observed 48h later. This PMS-induced increase in the estrogen concentration was also not affected by the treatment with various doses of PRL. From these results, it seems likely that exogenously administered PRL may be unable to suppress the ovarian responsiveness to gonadotropins by direct action on the ovary.
社団法人日本内分泌学会の論文