Serum Concentrations of 3, 3-Diiodothyronine, 3, 5-Diiodothyronine, and 3, 5-Diiodothyronine in Altered Thyroid States
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概要
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To investigate the thyroid hormone metabolism in altered states of thyroid function, serum concentrations of 3, 3-diiodothyronine (3, 3-T2), 3, 5-T2 and 3, 5-T2 as well as T4, T<SUB>3</SUB> and rT<SUB>3</SUB> were determined by specific radioimmunoassays in 17 hyperthyroid and 10 hypothyroid patients, before and during the treatment. Serum T4, T<SUB></SUB>3, rT<SUB>3</SUB>, 3, 3-T2 and 3, 5-T2 concentrations were all higher in the hyperthyroid patients than in age-matched controls and decreased to the normal ranges within 3 to 4 months following treatment with antithyroid drugs. In the hypothyroid patients, these iodothyronine concentrations were lower than in age-matched controls and returned to the normal ranges after 2 to 3 months treatment with T<SUB>4</SUB>. In contrast, serum 3, 5-T<SUB>2</SUB> concentrations in hyperthyroid patients (mean±SE: 4.0±0.5ng/dl) were not significantly different from those in controls (3.9±0.4ng/dl), although they tended to decrease in 3 of 6 patients after the antithyroid drug therapy. Serum 3, 5-T<SUB>2</SUB> levels in the hypothyroid patients (3.8±0.6ng/dl) were also within the normal range and showed no significant change following the T<SUB>4</SUB> replacement therapy. However, serum 3, 5-T<SUB>2</SUB> as wellas 3, 3-T<SUB>2</SUB> concentrations rose significantly with a marked rise in serum T<SUB>3</SUB> following T<SUB>3</SUB> administration, 75μg/day for 7days, in Graves patients in euthyroid state. These results indicate that serum concentrations of 3, 3-T<SUB>2</SUB> and 3, 5-T<SUB>2</SUB> well reflect the thyroid function states, but that serum 3, 5-T<SUB>2</SUB> concentrations change little in altered thyroid function states, although it is monodeiodinated from T3 in vivo.
- 社団法人 日本内分泌学会の論文
著者
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Inada Mitsuo
Second Department Of Internal Medicine Kansai Medical University
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Nishikawa Mitsushige
Second Department Of Internal Medicine Division Of Cardiology Kansai Medical University
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MASHIO YASUO
Kin-Ikyo Sapporo Clinic
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Imura Hiroo
Second Division Department Of Medicine Kyoto University School Of Medicine
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NAITO KOICHI
Department of Health and Enviroment, Hyogo Prefecture
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ISHII HITOSHI
Second Division, Department of Internal Medicine, Kyoto University
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TANAKA KIYOSHI
Second Division, Department of Internal Medicine, Kyoto University
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MASHIO YASUO
Kin-ikyo Sapporo Hospital
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INADA MITSUO
Second Department of Internal Medicine, Kansai Medical University
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