The acute stimulatory effect of estrogen on gonadotropin release in gonadotropin-releasing hormone-primed women.
スポンサーリンク
概要
- 論文の詳細を見る
In order to prove the acute stimulatory effects of estrogen on pituitary gonadotropin release, we have performed the present experiments in 8 women with a hypergonadotropic state due to surgical castration or primary ovarian failure. They received gonadotropin releasing hormone (Gn-RH) for 12-21 h at the constant rate of 20 μg/h. In 5 of the women, estradiol-17β was concomitantly administered at the rate of 20 μg/h from 6 h after the start of Gn-RH infusion. Blood samples were collected frequently throughout the experiments for the analysis of LH, FSH and estradiol.<BR>In response to the sole stimulation of Gn-RH, remarkable and prompt rises in LH (313.5%), but to a lesser degree in FSH (194.2%), were abserved within the initial 3 h, and their high levels were maintained throughout the experimental period. However, the additional administration of estradiol brought on a further sudden rise in both gonadotropins levels: 178.3% for LH and 163.5% for FSH within 2 h. These high levels were sustained during estradiol infusions. In 2 of them, blood samples were obtained for several hours after cessation of estradiol infusion. The circulating gonadotropin level dropped precipitously close to the baseline level within 3 h after estradiol infusions.<BR>Our data indicate that estrogen has an acute and strong augmentative effect on Gn-RH induced gonadotropin release in addition to its conventional negative and positive feedback effects.
- 一般社団法人 日本内分泌学会の論文
一般社団法人 日本内分泌学会 | 論文
- 性ホルモンと生体反応
- A Hexapeptide Angiotensin Antagonist, [Des-(Asp1, Arg2), Ile8]-Angiotensin II
- 甲状腺ホルモンの吸収に関する研究
- DISC ELECTROPHORETIC ANALYSIS OF GROWTH HORMONE AND PROLACTIN IN THE ANTERIOR PITUITARY OF MOUSE
- 機能性甲状腺結節 (Autonomous Functioning Thyroid Nodule) 及び周辺組織におけるヨード代謝