Identification of Novel Short Peptide Inhibitors of Soluble 37/48 kDa Oligomers of Amyloid β42

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概要

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• Since the soluble oligomers of 42-residue amyloid β (Aβ42) might be neurotoxins at an early stage of Alzheimer’s disease (AD), inhibition of soluble Aβ42 oligomerization should be effective in the treatment of AD. We have found by phage display that a 7-residue peptide, SRPGLRR, exhibited inhibitory activity against soluble 37/48 kDa oligomers of Aβ42. In the present study, we newly prepared 3- and 4-residue random peptides libraries and performed pannings of them against soluble Aβ42 to search for important factors in the inhibition of Aβ42 oligomerization. After the fifth round, arginine-containing peptides were enriched in both libraries. SDS–PAGE and size-exclusion chromatography indicated that the inhibitory activities of 4-residue peptides against the soluble 37/48 kDa oligomers of Aβ42 were higher than those of the 3-residue peptides, and RFRK exhibited strong inhibitory activity as well as SRPGLRR. These short peptides should be useful for the suppression of soluble Aβ42 oligomer formation.

• 社団法人 日本農芸化学会の論文

著者

• ONODERA Kenji

  Institute of Industrial Science, The University of Tokyo

• KAMIJO Shunsuke

  Institute of Industrial Science, The University of Tokyo

• Onodera Kenji

  The University Of Tokyo Institute Of Industrial Science

• Kawasaki Takayasu

  The University Of Tokyo Institute Of Industrial Science

• KAWASAKI Takayasu

  Institute of Industrial Science, The University of Tokyo

関連論文

• Reduction of misacylation to the amber suppressor tRNA during site-specific incorporation of unnatural amino acids
• Analyses of Conditions for KMSSS Loop in Tyrosyl-tRNA Synthetase by Building a Mutant Library
• Selection of Peptide Inhibitors of Soluble Aβ1-42 Oligomer Formation by Phage Display
• Analyses of Conditions for KMSSS Loop in Tyrosyl-tRNA Synthetase by Building a Mutant Library
• Selection of Peptide Inhibitors of Soluble Aβ_ Oligomer Formation by Phage Display
• Identification of Novel Short Peptide Inhibitors of Soluble 37/48 kDa Oligomers of Amyloid β42
• Identification of Novel Short Peptide Inhibitors of Soluble 37/48kDa Oligomers of Amyloid β42
• Inhibition of Aggregation of Amyloid β42 by Arginine-Containing Small Compounds

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