大環状ポリアミン (アザクラウン) 化合物の合成と機能について

概要

論文の詳細を見る
Macrocyclic polyamines are a new class of functional molecules. They show (1) special features of mode of their proton uptake; (2) uptake of biological polyanions (such as TCA cycle polycarboxylates, phosphate, ATP and carbonate) and of catechols (such as dopa and dapamine); (3) selective inclusion of some transition metal ions (e. g. CuII); (4) selective uptake of hard metal ions (e. g. MgII); (5) peptide-like functions to stabilize unusual oxiadtion state of metal ions (e. g. CuIII, NiIII); (6) superoxide dismutase-like activities by macrocyclic polyamine complexes; (7) heme-like O2-uptake and activation functions by metal complexes; and (8) functions of phenolate-coordinate heme enzymes. These newly discovered properties will prove to be useful for the future development of entirely new type of medicines, chemicals, catalysts and so on.
社団法人有機合成化学協会の論文