カルベンを利用する炭素-炭素結合形成反応の新しい展開

概要

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Novel carbon-carbon bond forming reactions of carbenes reported in the last several years are selected and reviewed from a synthetic viewpoint. The major part of this article deals with regioselective and efficient C-H insertion reactions selected on the basis of, 1) geometrically controlled intramolecular pathway, 2) chemical modification of substrates, such as substitution by negative charge which activates a neighboring C-H bond, and 3) control of both reactivity and regiochemistry by manipulating metal catalysts. Control of intramolecular 1, 2-H shifts is also described in connection with the C-H insertion. The second part consists of electrophilic reactions of carbenes with carbon nucleophiles as well as with hetero atom functional groups through ylide formation. Other sections deal with cycloaddition reactions such as 1, 4- and homo-1, 4-additions, dipolar cycloadditions, additions to strained sigma bonds, and Skattebøl-type carbene-carbene rearrangements. 1, 2-Additions to double bonds, insertion to O-H, N-H bonds are omitted from discussion.
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