光学活性カルボニル化合物への高選択的求核付加反応を利用する鎖状化合物の立体制御法

概要

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This article describes the attractive method for construction of acyclic systems using diastereoselective addition reactions of nucleophiles with chiral carbonyl compounds. The following topics are included : (a) the diastereofacial selective addition reaction of α-alkyl-β-trimethylsilyl-β, γ-unsaturated carbonyl compounds with nucleophiles and its application to the synthesis of some natural products including macrolides, (b) the addition reaction of Grignard reagents with α-alkoxy-β-trimethylsilyl-β, γ-unsaturated carbonyl compounds which affords the convenient method for construction of 1, 2-diol derivatives, and (c) the synthesis of the rarely obtained <I>syn</I>-adducts in the reaction of organocopper compounds with glyceraldehyde acetonide.
社団法人有機合成化学協会の論文