生体触媒を利用するプロセスケミストリーへの挑戦
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概要
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Biocatalysts are versatile tools for the quick synthesis of single enantiomers by not only kinetic resolution of racemates but desymmetrization of prochiral substrates. However, the theoretical yield of resolution is 50%. To circumvent the problem, enzymatic or non-enzymatic racemization method are investigated. Dynamic kinetic resolution (DKR) will be able to afford the desired product with high chemical yield and high enantiomeric excess in a one-pot reaction. Multi-enzyme system is an effective method. The combination of two types of dehydrogenases is useful to obtain secondary alcohols and amines. The utilization of genetically modified microorganism, in which the genes of those dehydrogenases are inserted, is an attractive synthetic process as whole cell biocatalysts.