1,7-クレーブ酸の新工業的製造研究

概要

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Until the completion of this investigation 1, 7-Cleve acid has been produced in an industrial scale by sulfonation of naphthalene, followed by nitration and reduction. However, its separation from accompanying 1, 6-Cleve acid, Peri-acid and others is not so easy, and it has been difficult to obtain the acid in pure form enough for industrial use.<BR>The authors have succeeded in synthesizing the acid by sulfonation of 1-naphthol followed by hydrolysis and Bucherer reaction.<BR>(1) Hydrolysis of di-sulfonated naphthol to mono-sulfonic acid directly by use of the remaining sulfuric acid. <BR>(2) Addition of ammonia and ammonium bisulfite to the sodium 1-naphthol-7-sulfonate solution (obtained by sodation of calcium 1-naphthol-7-sulfonate solution separated by liming the mixture of the monosulfonic and sulfuric acid solution) and heating the mixture.<BR>The process is now established and has been already carried out since a few years ago.
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