ゼロ価ニッケル錯体触媒を用いるアセチレン化合物と二酸化炭素およびアルデヒドの反応

概要

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Transition metal-catalyzed carbon dioxide fixation into unsaturated hydrocarbons is an important problem. On the basis of two new approaches, i.e., use of reactive substrates of diynes and alkoxyacetylenes and synthesis of a trialkylphosphine ligand containing a pyridyl functional group, we have developed an efficient and selective nickel (0) -catalyzed cycloaddition reaction of acetylenes with carbon dioxide to various 2-pyrones. By the use of aldehydes instead of carbon dioxide, we have also developed a nickel (0) tertiary phosphine complex-catalyzed reaction of diynes and monoynes with aldehydes, which provides synthetic methods of bicyclic 2<I>H</I>-pyrans, functionalized carbo and heterocycles and α, β-enones.
社団法人有機合成化学協会の論文