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1. Development of the New Concept of “Reaction Field” A new concept of “reaction field” as a specific force field which is important in determing direction, velocity or selectivity of a reaction is briefly introduced and discussed. 2. Factors Determining “Reaction Field.” As major factors determining above defined “reaction field” in biological systems, (a) hydrophobic field, (b) asymmetric field, (c) electrostatic field and (d) information field are discussed. Unique substrate specificity developed in a hydrophobic cavity of chymotrypsin, specific hydrogen transfer between alcohol dehydrogenase and NADD, metal coordination in pyruvate carboxylase catalysis and information field in nucleic acids and proteins are presented as typical examples for (a) - (d), respectively. 3. Practical Design of “Reaction Field.” Designing of hydrophobic field by use of cyclodextrin and cyclophane host, designing of electrostatic field by introducing additional cations onto some host molecules, designing of asymmetric field by attaching asymmetric wall to crown ethers, designing of information fiels by connecting “information elements” by covalent bonds are specially discussed. 4. Specific Reaction in Reaction Field. Specific reactions originated from specific “reaction field” are discussed for (a) energy conversion (b) electron transport (c) electron conjugated shift and (d) active transport. Artificially composed photosynthesis model, electron transport system, CPA hydrolysis and active transport across membrane are taking special examples, respectively. 5. Organic Synthesis by Effective Utilization of “Reaction Field.” Specific and automatic ADP synthesis from AMP, prenyl condensation in cyclodextrin cavity and some other examples are discussed.
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