ビタミンB<SUB>12</SUB>の生化学における最近の進歩

スポンサーリンク

概要

• 論文の詳細を見る

• Recent advances in studies on the mechanism of action of vitamin B<SUB>12</SUB> coenzymes and on the biosynthesis of vitamin B12 are reviewed. Adenosyl-B<SUB>12</SUB> is the first known naturally occurring organometallic compound containing a stable Co-C sigma bond. This coenzyme participates in the eleven seemingly different enzymatic rearrangement and reduction reactions, and has been well established to act as an intermediate hydrogen carrier. It is generally accepted that the early event in the reactions is the cleavage of the Co-C bond of the enzyme-bound coenzyme, which leads to generation of the catalytic center. A possible role of the apoprotein in activation of the Co-C bond of the coenzyme, which is essential for manifestation of functions of the coenzyme, is discussed on the bases of the structure-function relationship of B<SUB>12</SUB> coenzymes in the diol dehydrase reaction and of the apoenzyme-coenzyme interactions. The biosynthetic route for vitamin B<SUB>12</SUB> is also briefly summarized here with emphasis on the ring contraction step in formation of the corrin nucleus.

• 社団法人 有機合成化学協会の論文

著者

• 虎谷 哲夫

  京都大学工学部工業化学教室

関連論文

• メタノール資化細菌によるビタミンB_の生産
• ビタミンB12の生化学における最近の進歩
• ビタミンB_のサクシニル誘導体 : その調製と生化学的性質
• ビタミンB_補酵素の構造と機能の関係 : 補酵素アナログを用いた研究
• 共有結合で酵素たんぱくに結合しているフラビン

スポンサーリンク