シクロプロパンアミノ酸の合成と立体制約因子としての生理活性ペプチドへの導入

概要

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Cyclopropane amino acids are the amino acid derivatives which contain the cyclopropane ring in their side chain. Various cyclopropane amino acids were isolated from many different natural sources. Along with many efforts to synthesize these natural compounds, studies on the structure-activity relationships of bioactive peptides have highlighted the usefulness of cyclopropane amino acids. Incorporation of cyclopropane amino acids has been achieved for some neuropeptides, hormones, and enzyme inhibitors and these sterically rigid cyclopropane amino acids were found to be a key constituent not only as conformational constraint but also as a structural element to avoid enzymatic degradations. Several distinct success stories have prompted organic chemists to challenge the asymmetric synthesis of optically active cyclopropane amino acids in these years.
社団法人有機合成化学協会の論文