微生物酵素法によるヌクレオシド系生理活性物質の生産

概要

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Synthesis of biologically interesting nucleosides by a combination of chemical and enzymatic reactions is reviewed. As a likely source of enzyme, Enterobacter aerogenes was selected and its nucleoside phosphorylases were found to catalyze a transglycosyl reaction between pentofuranose and purine or pyrimidine base at relatively high temperature of 60°C. Using this procedure, a variety of nucleoside analogs and nucleosidic antibiotics which have been shown to have antiviral or antitumor activity were synthesized. Noteworthy among them are adenine arabinoside, guanine arabinoside, 2-amino-2-deoxyadenosine, 2-amino -2-deoxyguanosine and Virazole. It is of special interest that adenine arabinoside can be produced in a good yield with ease and on a large scale. Furthermore, it is reported that the methodology also serves for the preparation of new biologically interesting nucleosides.
社団法人有機合成化学協会の論文