魚類血液の酵素に関する研究-II : 有機燐殺虫剤のコリンエステラーゼ活性度に及ぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Recently a group of organophosphorus compounds has appeared as a new type of very powerful inhibitors of esterase, some of which being extremely toxic especially for nervorus systems. Among them, some are specific inhibitor of enzymes capable of splitting ester linkages, trypsin, chymotrypsin and thrombin. However, the lethal effect must be due as well to the inhibition of cholinesterase. The present report of our serial research is concerned with the inhibition of some of the insecticides on the activity of carp blood cholinesterase; and its results are summarized as follows: 1) Inhibition as much as 48-54 percent of serum cholinesterase activity was observed at 1-25ppm of parathion which is the lethal concentration for carp; and the same could be said with the one from erythrocyte. Parathion less than 0.001ppm did not show any inhibitory effect on the activity of these cholinesterases (Fig. 1). 2) Malathion at levels 1-25ppm inhibited the 20-30 percent activity of cholinesterase purified from serum. But any inhibitory effect on the activity of the cholinesterase could not be found out at the concentration of malathion less than 0.01ppm (Fig. 2). 3) Inhibition of serum cholinesterase by endrin was so low as 2-8 percent even at its lethal concentration (0.05-0.005ppm) (Fig. 3). These facts may suggest the possibility that the carp blood cholinesterases are not inhibited by endrin which is one of the organic chlorine insecticides commonly used in our country.
- 公益社団法人 日本水産学会の論文