A Novel Point Mutation of the RET Proto-oncogene in Small Cell Lung Carcinoma Cell Lines.
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概要
- 論文の詳細を見る
Point mutations of the RET proto-oncogene are associated with the development of inherited diseases including multiple endocrine neoplasia (MEN) type 2, familial medullary thyroid carcinoma (MTC), and Hirschsprung's disease as well as a part of sporadic MTCs and pheochromocytomas. In the present study, we examined point mutations of the RET proto-oncogene in exons 10, 11 and 16 in small cell lung carcinoma (SCLC) cell lines. A novel point mutation from GCC to GAC at colon 664 in exon 11 was identified in 2 out of 6 SCLC cell lines; this alteration results in an amino acid substitution of aspartic acid for alanine. This point mutation was not detected in other types of cancer cell lines so far examined. Point mutations of the RET proto-oncogene reported previously inexons 10, 11 and 16 in above-mentioned diseases were not detected in the SCLC cell lines. These results suggest that this point mutation of the RET proto-oncogene is closely associated with a part of SCLC.
- 日本学士院の論文
著者
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YAMAGUCHI Ken
Growth Factor Division National Cancer Center Research Institute
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FUTAMI Hitoyasu
Growth Factor Division, National Cancer Center Research Institute
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Futami Hitoyasu
Growth Factor Division National Cancer Center Research Institute
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EGAWA Shin-ichi
Growth Factor Division, National Cancer Center Research Institute
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Egawa Shin-ichi
Growth Factor Division National Cancer Center Research Institute
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