The NGFI-B Family: Orphan Nuclear Receptors of the Steroid/Thyroid Receptor Superfamily
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概要
- 論文の詳細を見る
The steroid/thyroid receptor superfamily comprises a group of structurally related transcription factors that program developmental, physiological, and behavioral responses to a variety of signals. NGFI-B, Nurr1 and NOR-1 are members of this superfamily of ligand-inducible transcription factors, and constitute one subgroup called the NGFI-B family. However, ligands have not yet been identified for the family members, and therefore they also belong to the category of “orphan receptors.” Although our knowledge of the NGFI-B family is limited, it is clear that these transcription factors have important functions in mediating responses to various signals and play critical roles in biological processes including cell growth, differentiation and apoptosis. In this review, we summarize their structural features, genomic organization, gene expression and transcriptional regulation, and illustrate their biological functions inferred from recent reports.
- 日本繁殖生物学会の論文
著者
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TSUKADA Toshihiko
Growth Factor Division National Cancer Center Research Institute
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YAMAGUCHI Ken
Growth Factor Division National Cancer Center Research Institute
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Ohkura Naganari
Growth Factor Division, National Cancer Center Research Institute,5-1-1 Tsukiji,Chuo-ku, Tokyo 104-0
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Maruyama Kouji
Growth Factor Division, National Cancer Center Research Institute,5-1-1 Tsukiji,Chuo-ku, Tokyo 104-0
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HOSONO Tetsuji
Growth Factor Division, National Cancer Center Research Institute,5-1-1 Tsukiji,Chuo-ku, Tokyo 104-0
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Tsukada Teruyo
Growth Factor Division National Cancer Research Institute
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