Genetic Control of Soluble HLA Antigen Levels in Serum

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概要

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• HLA-A2, -A9, and -A10 antigen titers in serum were assessed by the lymphocytotoxicity inhibition test on family bloods of neonates (cord bloods) and parents in order to investigate their genetic control. (1) Serum HLA-A9 and -A10 antigens were distributed among parents with higher titers than neonates, while serum HLA-A2 antigen was found with almost equal titers among parents and neonates. (2) Correlation of serum HLA antigen titers was calculated between parents and neonates: A2 and A9 antigen titers showed positive correlations. AIM antigen was hardly detectable in sera of neonates. (3) Neonates whose parents were weak inhibitors had low titers of that antigen, while neonates of strong inhibitor parents had high or low titers. (4) Discrepancy was observed among the HLA antigen titers of different specificities in heterozygous individuals. It was difficult to group individuals into secretors and nonsecretors of whole HLA antigens.

著者

• Hara Masaaki

  Department Of Forensic Medicine Faculty Of Medicine Saitama Medical University

• HASEKURA Hayato

  Department of Legal Medicine, Tokyo Medical and Dental University School of Medicine

• Kaneko Kazuhiko

  Department Of Electrical Engineering School Of Science And Engineering Waseda University

• Yoshimura Kouichi

  Department Of Biological Science And Technology Science University Of Tokyo

• Tamura Takeshi

  Department Of Internal Medicine School Of Medicine Keio University

• YANAGIDA Jun-ichi

  Department of Legal Medicine, Saitama Medical School

• KASHIMURA Yoshio

  Department of Obstetrics and Gynecology, Saitama Medical School

• AKAMINE Kazunori

  Department of Obstetrics and Gynecology, Saitama Medical School

• HASEKURA Hayato

  Department of Legal Medicine, Saitama Medical School

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